Medication | Class | Usage | Trade Names | Dosage | Common Side Effects |
|---|---|---|---|---|---|
GnRH Antagonist | Ovarian SuppressionPrevention of Premature Ovulation | Orgalutran; Cetrotide | 250 µg from cycle day 5 of stimulation phase until hCG administration | Nausea, Headaches | |
GonadotrophinFSH | Ovarian StimulationOvulation Induction | Follistim, Gonal-F | 75-300 IU/day for up to 30 days | Gastrointestinal disturbances, headache, joint pain, fever | |
Selective Estrogen Receptor Modulator (SERM)Anti-Estrogen | Ovulation InductionOvarian Stimulation | Clomid; Clomifene (generic); Serophene | 5-150mg/day, days 1-5 of menstrual cycle | Hot flashes, abdominal discomfort | |
GonadotrophinFSHLH | Ovarian StimulationOvulation Induction | Menopur; Merional; Repronex | 150-450 IU/day for ~ 12 days | Gastrointestinal disturbances; headaches, joint pain, fever | |
Pulsed LHRH/GnRH | Ovulation InductionOvarian Stimulation | Factrel; Lutrepulse | 5 µg every 90 minutes. Can increase incrementally up to 20 µg per 90 minute pulse | Rarely nausea, headaches, abdominal pain, increased menstrual bleeding | |
GonadotrophinFSH | Ovarian StimulationOvulation Induction | Bravelle; Fertinorm HP, Fostimon | 150-450 IU/day for ~ 12 days | Gastrointestinal disturbances; headaches, joint pain, fever | |
GonadotrophinLH | Ovulation InductionOvarian Stimulation | Luveris | 75-300 IU/day for up to 30 days | Nausea, vomiting, abdominal and pelvic pain, headaches, somnolence | |
Chorionic Gonadotrophin | Oocyte Maturation | Ovidrel; Ovitrelle | 250 µg injection day after last dose of gonadotrophin | Nausea, vomiting, abdominal pain, headache, tiredness | |
GnRH Agonist | Ovarian SuppressionPrevention of Premature Ovulation | Suprefact; Synarel | Buserelin/Suprefact: 200-500 µg daily injection; Nafarelin/Synarel: 200 µg spray in nostril daily | Menopausal Sx, such as hot flushes, increased sweating, vaginal dryness, dyspareunia, loss of libido, headaches | |
Chorionic Gonadotrophin | Oocyte Maturation | Pregnyl | 5000-10,000 IU injection day after last dose of gonadotrophin | Edema, headache, tiredness, mood changes, gynecomastia |